@article {230, title = {Childhood aggression and the co-occurrence of behavioural and emotional problems: results across ages 3{\textendash}16~years from multiple raters in six cohorts in the EU-ACTION project}, journal = {European Child {\&} Adolescent Psychiatry}, year = {2018}, month = {May}, abstract = {

Childhood aggression and its resulting consequences inflict a huge burden on affected children, their relatives, teachers, peers and society as a whole. Aggression during childhood rarely occurs in isolation and is correlated with other symptoms of childhood psychopathology. In this paper, we aim to describe and improve the understanding of the co-occurrence of aggression with other forms of childhood psychopathology. We focus on the co-occurrence of aggression and other childhood behavioural and emotional problems, including other externalising problems, attention problems and anxiety\–depression. The data were brought together within the EU-ACTION (Aggression in Children: unravelling gene-environment interplay to inform Treatment and InterventiON strategies) project. We analysed the co-occurrence of aggression and other childhood behavioural and emotional problems as a function of the child\&$\#$39;s age (ages 3 through 16\ years), gender, the person rating the behaviour (father, mother or self) and assessment instrument. The data came from six large population-based European cohort studies from the Netherlands (2x), the UK, Finland and Sweden (2x). Multiple assessment instruments, including the Child Behaviour Checklist (CBCL), the Strengths and Difficulties Questionnaire (SDQ) and Multidimensional Peer Nomination Inventory (MPNI), were used. There was a good representation of boys and girls in each age category, with data for 30,523 3- to 4-year-olds (49.5{\%} boys), 20,958 5- to 6-year-olds (49.6{\%} boys), 18,291 7- to 8-year-olds (49.0{\%} boys), 27,218 9- to 10-year-olds (49.4{\%} boys), 18,543 12- to 13-year-olds (48.9{\%} boys) and 10,088 15- to 16-year-olds (46.6{\%} boys). We replicated the well-established gender differences in average aggression scores at most ages for parental ratings. The gender differences decreased with age and were not present for self-reports. Aggression co-occurred with the majority of other behavioural and social problems, from both externalising and internalising domains. At each age, the co-occurrence was particularly prevalent for aggression and oppositional and ADHD-related problems, with correlations of around 0.5 in general. Aggression also showed substantial associations with anxiety\–depression and other internalizing symptoms (correlations around 0.4). Co-occurrence for self-reported problems was somewhat higher than for parental reports, but we found neither rater differences, nor differences across assessment instruments in co-occurrence patterns. There were large similarities in co-occurrence patterns across the different European countries. Finally, co-occurrence was generally stable across age and sex, and if any change was observed, it indicated stronger correlations when children grew older. We present an online tool to visualise these associations as a function of rater, gender, instrument and cohort. In addition, we present a description of the full EU-ACTION projects, its first results and the future perspectives.

Related interactive tool here.

}, issn = {1435-165X}, doi = {10.1007/s00787-018-1169-1}, url = {https://doi.org/10.1007/s00787-018-1169-1}, author = {Meike Bartels and Anne Hendriks and Matteo Mauri and Eva Krapohl and Alyce Whipp and Koen Bolhuis and Conde, Lucia Colodro and Luningham, Justin and Fung Ip, Hill and Fiona Hagenbeek and Roetman, Peter and Gatej, Raluca and Lamers, Audri and Michel G. Nivard and Jenny van Dongen and Lu, Yi and Christel Middeldorp and van Beijsterveldt, Toos and Vermeiren, Robert and Thomas Hankemeier and Kluft, Cees and Medland, Sarah and Lundstr{\"o}m, Sebastian and Richard J. Rose and Pulkkinen, Lea and Vuoksimaa, Eero and Korhonen, Tellervo and Martin, Nicholas G. and Gitta Lubke and Catrin Finkenauer and Vassilios Fanos and Henning Tiemeier and Lichtenstein, Paul and Robert Plomin and Kaprio, Jaakko and Dorret I. Boomsma} } @article {239, title = {Selected Lectures of the 14th International Workshop on Neonatology. LECT 33, Sharing research: communication can help}, journal = {Journal of Pediatric and Neonatal Individualized Medicine (JPNIM)}, volume = {7}, year = {2018}, month = {10/2018}, pages = {41-43}, type = {Proceedings of the 14{\textdegree} International Workshop on Neonatology, The revolution of microbiomics, Cagliari (Italy), October 24-27}, doi = {10.7363/070238}, url = {http://www.jpnim.com/index.php/jpnim/article/view/070238}, author = {Matteo Mauri and Vassilios Fanos} } @article {240, title = {Selected Lectures of the 14th International Workshop on Neonatology. LECT 31, Unraveling the complex genetics of childhood and adolescent psychopathology, including aggression, through international collaborations: update on the CAPICE and ACTION projects}, journal = {Journal of Pediatric and Neonatal Individualized Medicine (JPNIM)}, volume = {7}, year = {2018}, month = {10/2018}, pages = {38-39}, type = {Proceedings of the 14{\textdegree} International Workshop on Neonatology, The revolution of microbiomics, Cagliari (Italy), October 24-27}, doi = {10.7363/070238}, url = {http://www.jpnim.com/index.php/jpnim/article/view/070238}, author = {Mirko Manchia and Vassilios Fanos} } @article {212, title = {Selected Abstracts of the 13th International Workshop on Neonatology. ABS 72, An interactive tool shows comorbidities of child aggression with other childhood psychopathologies. Utilities and statistics of the website www.action-euproject.eu}, journal = {Journal of Pediatric and Neonatal Individualized Medicine (JPNIM)}, volume = {6}, year = {2017}, month = {10/2017}, type = {Proceedings of the 13{\textdegree} International Workshop on Neonatology, Twins: identical but different, Cagliari (Italy), October 25-28}, doi = {10.7363/060234}, url = {http://www.jpnim.com/index.php/jpnim/article/view/060234/468}, author = {Matteo Mauri and Anne Hendriks and Vassilios Fanos and Dorret I. Boomsma and Meike Bartels} } @article {208, title = {Selected Lectures of the 13th International Workshop on Neonatology. LECT 71, Aggressiveness from fetus to adult: the twins case}, journal = {Journal of Pediatric and Neonatal Individualized Medicine (JPNIM)}, volume = {6}, year = {2017}, month = {10/2017}, pages = {97-98}, type = {Proceedings of the 13{\textdegree} International Workshop on Neonatology, Twins: identical but different, Cagliari (Italy), October 25-28}, abstract = {

PDF Available here

}, keywords = {13th International Workshop on Neonatology, 2017, Cagliari}, doi = {10.7363/060235}, url = {http://www.jpnim.com/index.php/jpnim/article/view/060235/467}, author = {Pintus, Roberta and Dess{\`\i}, Angelica and Antonio Noto and Vassilios Fanos} } @article {209, title = {Selected Lectures of the 13th International Workshop on Neonatology. LECT 70, Integrating microbiomics and metabolomics data in behavioral complex traits: a role in aggression?}, journal = {Journal of Pediatric and Neonatal Individualized Medicine (JPNIM)}, volume = {6}, year = {2017}, month = {10/2017}, pages = {96}, type = {Proceedings of the 13{\textdegree} International Workshop on Neonatology, Twins: identical but different, Cagliari (Italy), October 25-28}, abstract = {

PDF Available here

}, keywords = {13th International Workshop on Neonatology, 2017, Aggression, Cagliari}, doi = {10.7363/060235}, url = {http://www.jpnim.com/index.php/jpnim/article/view/060235/467}, author = {Mirko Manchia and Vassilios Fanos} } @article {170, title = {Targeting aggression in severe mental illness: the predictive role of genetic, epigenetic, and metabolomic markers}, journal = {Progress in Neuro-Psychopharmacology and Biological Psychiatry}, volume = {77,}, year = {2017}, month = {07/2017}, pages = {32{\textendash}41}, abstract = {

Human aggression is a complex and widespread social behavior that is overrepresented in individuals affected by severe mental illness (SMI), such as schizophrenia (SCZ), bipolar disorder (BD), autism spectrum disorder (ASD), and attention-deficit/hyperactivity disorder (ADHD). A substantial proportion of the liability threshold for aggressive behavior is determined by genetic factors, and environmental moderators might precipitate the manifestation of this behavioral phenotype through modification of gene expression via the epigenetic machinery. These specific alterations in the genetic and epigenetic make-up of aggressive individuals might determine distinct biochemical signatures detectable through metabolomics. An additional pathophysiological component playing a role in aggressive behavior might be determined by alterations of gut microbiota. Here, we present a selective review of human data on genetic, epigenetic, and metabolomic markers of aggressive behavior in SMI, discussing also the available evidence on the role of microbiome alterations. Clinical implication of these evidences, as well as future perspectives, will be discussed.

}, doi = {http://doi.org/10.1016/j.pnpbp.2017.03.024}, author = {Mirko Manchia and Vassilios Fanos} } @article {162, title = {Fetal programming of neuropsychiatric disorders.}, journal = {Birth Defects Res C Embryo Today}, volume = {108}, year = {2016}, month = {2016 Sep}, pages = {207-223}, abstract = {

Starting from the Developmental Origins of Health and Disease (DOHaD) hypotheses proposed by David Barker, namely fetal programming, in the past years, there is a growing evidence of the major role played by epigenetic factors during the intrauterine life and the perinatal period. Furthermore, it has been assessed that these factors can affect the health status in infancy and even in adulthood. In this review, we focus our attention on the fetal programming of the brain, analyzing the most recent literature concerning the epigenetic factors that can influence the development of neuropsychiatric disorders such as bipolar disorders, major depressive disorders, and schizophrenia. The perinatal epigenetic factors have been divided in two main groups: maternal factors and fetal factors. The maternal factors include diet, smoking, alcoholism, hypertension, malnutrition, trace elements, stress, diabetes, substance abuse, and exposure to environmental toxicants, while the fetal factors include hypoxia/asphyxia, placental insufficiency, prematurity, low birth weight, drugs administered to the mother or to the baby, and all factors causing intrauterine growth restriction. A better comprehension of the possible mechanisms underlying the pathogenesis of these diseases may help researchers and clinicians develop new diagnostic tools and treatments to offer these patients a tailored medical treatment strategy to improve their quality of life. Birth Defects Research (Part C) 108:207-223, 2016. \© 2016 Wiley Periodicals, Inc.

}, issn = {1542-9768}, doi = {10.1002/bdrc.21139}, author = {Faa, Gavino and Mirko Manchia and Pintus, Roberta and Gerosa, Clara and Marcialis, Maria Antonietta and Vassilios Fanos} } @article {78, title = {Selected Abstracts of the 11th International Workshop on Neonatology. ABS 100, Brain misteries from the womb to the adult: is aggression congenital?}, journal = {Journal of Pediatric and Neonatal Individualized Medicine (JPNIM)}, volume = {4}, year = {2015}, month = {10/2015}, pages = {231}, type = {Proceedings of the 11{\textdegree} International Workshop on Neonatology and Satellite Meetings, Cagliari (Italy), October 26-31}, abstract = {

PDF Available here

}, doi = {10.7363/040249}, url = {http://www.jpnim.com/index.php/jpnim/article/view/040249}, author = {Mirko Manchia and Vassilios Fanos} } @article {77, title = {Selected Abstracts of the 11th International Workshop on Neonatology. ABS 84, Biomarkers of aggression: metabolomics}, journal = {Journal of Pediatric and Neonatal Individualized Medicine (JPNIM)}, volume = {4}, year = {2015}, month = {10/2015}, pages = {210-211}, type = {Proceedings of the 11{\textdegree} International Workshop on Neonatology and Satellite Meetings, Cagliari (Italy), October 26-31}, abstract = {

PDF Available here

}, keywords = {11th International Workshop on Neonatology, 2015, Cagliari}, doi = {10.7363/040249}, url = {http://www.jpnim.com/index.php/jpnim/article/view/040249}, author = {Antonio Noto and Vassilios Fanos} }