@article {460,
	title = {Genome-wide association meta-analysis identifies 29 new acne susceptibility loci},
	journal = {Nature Communications},
	volume = {13},
	year = {2022},
	pages = {702},
	abstract = {<p>Acne vulgaris is a highly heritable skin disorder that primarily impacts facial skin. Severely inflamed lesions may leave permanent scars that have been associated with long-term psychosocial consequences. Here, we perform a GWAS meta-analysis comprising 20,165 individuals with acne from nine independent European ancestry cohorts. We identify 29 novel genome-wide significant loci and replicate 14 of the 17 previously identified risk loci, bringing the total number of reported acne risk loci to 46. Using fine-mapping and eQTL colocalisation approaches, we identify putative causal genes at several acne susceptibility loci that have previously been implicated in Mendelian hair and skin disorders, including pustular psoriasis. We identify shared genetic aetiology between acne, hormone levels, hormone-sensitive cancers and psychiatric traits. Finally, we show that a polygenic risk score calculated from our results explains up to 5.6\% of the variance in acne liability in an independent cohort.</p>
},
	doi = {10.1038/s41467-022-28252-5},
	author = {Mitchell, Brittany L and Saklatvala, Jake R and Dand, Nick and Hagenbeek, Fiona A and Li, Xin and Min, Josine L and Thomas, Laurent and Bartels, Meike and Jan Hottenga, Jouke and Lupton, Michelle K and Boomsma, Dorret I and Dong, Xianjun and Hveem, Kristian and L{\o}set, Mari and Martin, Nicholas G and Barker, Jonathan N and Han, Jiali and Smith, Catherine H and Renter{\'\i}a, Miguel E and Simpson, Michael A}
}
