@article {441,
	title = {Measurement and genetic architecture of lifetime depression in the Netherlands as assessed by LIDAS (Lifetime Depression Assessment Self-report)},
	journal = {Psychological Medicine},
	volume = {51},
	year = {2020},
	pages = {1{\textendash}10},
	abstract = {<p>BACKGROUND: Major depressive disorder (MDD) is a common mood disorder, with a heritability of around 34\%. Molecular genetic studies made significant progress and identified genetic markers associated with the risk of MDD; however, progress is slowed down by substantial heterogeneity as MDD is assessed differently across international cohorts. Here, we used a standardized online approach to measure MDD in multiple cohorts in the Netherlands and evaluated whether this approach can be used in epidemiological and genetic association studies of depression. METHODS: Within the Biobank Netherlands Internet Collaboration (BIONIC) project, we collected MDD data in eight cohorts involving 31 936 participants, using the online Lifetime Depression Assessment Self-report (LIDAS), and estimated the prevalence of current and lifetime MDD in 22 623 unrelated individuals. In a large Netherlands Twin Register (NTR) twin-family dataset (n $\approx$ 18 000), we estimated the heritability of MDD, and the prediction of MDD in a subset (n = 4782) through Polygenic Risk Score (PRS). RESULTS: Estimates of current and lifetime MDD prevalence were 6.7\% and 18.1\%, respectively, in line with population estimates based on validated psychiatric interviews. In the NTR heritability estimates were 0.34/0.30 (s.e. = 0.02/0.02) for current/lifetime MDD, respectively, showing that the LIDAS gives similar heritability rates for MDD as reported in the literature. The PRS predicted risk of MDD (OR 1.23, 95\% CI 1.15-1.3</p>
},
	keywords = {LIDAS, Lifetime Depression Assessment Self-report, major depressive disorder, online assessment tool, prevalence},
	doi = {10.1017/S0033291720000100},
	author = {Fedko, Iryna O and Hottenga, Jouke-Jan and Helmer, Quinta and Mbarek, Hamdi and Huider, Floris and Amin, Najaf and Beulens, Joline W and Bremmer, Marijke A and Elders, Petra J and Galesloot, Tessel E and Kiemeney, Lambertus A and van Loo, Hanna M and Picavet, H Susan J and Rutters, Femke and van der Spek, Ashley and van de Wiel, Anne M and van Duijn, Cornelia and de Geus, Eco J C and Feskens, Edith J M and Hartman, Catharina A and Oldehinkel, Albertine J and Smit, Jan H and Verschuren, W M Monique and Penninx, Brenda W J H and Boomsma, Dorret I and Bot, Mariska}
}
