@article {465, title = {Overview of CAPICE - Childhood and Adolescence Psychopathology: unravelling the complex etiology by a large Interdisciplinary Collaboration in Europe - an EU Marie Sk{\l}odowska-Curie International Training Network}, journal = {European Child \& Adolescent Psychiatry}, volume = {31}, year = {2022}, pages = {829{\textendash}839}, abstract = {

The Roadmap for Mental Health and Wellbeing Research in Europe (ROAMER) identified child and adolescent mental illness as a priority area for research. CAPICE (Childhood and Adolescence Psychopathology: unravelling the complex etiology by a large Interdisciplinary Collaboration in Europe) is a European Union (EU) funded training network aimed at investigating the causes of individual differences in common childhood and adolescent psychopathology, especially depression, anxiety, and attention deficit hyperactivity disorder. CAPICE brings together eight birth and childhood cohorts as well as other cohorts from the EArly Genetics and Life course Epidemiology (EAGLE) consortium, including twin cohorts, with unique longitudinal data on environmental exposures and mental health problems, and genetic data on participants. Here we describe the objectives, summarize the methodological approaches and initial results, and present the dissemination strategy of the CAPICE network. Besides identifying genetic and epigenetic variants associated with these phenotypes, analyses have been performed to shed light on the role of genetic factors and the interplay with the environment in influencing the persistence of symptoms across the lifespan. Data harmonization and building an advanced data catalogue are also part of the work plan. Findings will be disseminated to non-academic parties, in close collaboration with the Global Alliance of Mental Illness Advocacy Networks-Europe (GAMIAN-Europe).

}, keywords = {anxiety, Attention deficit hyperactivity disorder (ADHD), Childhood and adolescence psychopathology, Depression, Psychiatric genetics}, doi = {10.1007/s00787-020-01713-2}, author = {Rajula, Hema Sekhar Reddy and Manchia, Mirko and Agarwal, Kratika and Akingbuwa, Wonuola A and Allegrini, Andrea G and Diemer, Elizabeth and Doering, Sabrina and Haan, Elis and Jami, Eshim S and Karhunen, Ville and Leone, Marica and Schellhas, Laura and Thompson, Ashley and van den Berg, St{\'e}phanie M and Bergen, Sarah E and Kuja-Halkola, Ralf and Hammerschlag, Anke R and J{\"a}rvelin, Marjo Riitta and Leval, Amy and Lichtenstein, Paul and Lundstr{\"o}m, Sebastian and Mauri, Matteo and Munaf{\`o}, Marcus R and Myers, David and Plomin, Robert and Rimfeld, Kaili and Tiemeier, Henning and Ystrom, Eivind and Fanos, Vassilios and Bartels, Meike and Middeldorp, Christel M} } @article {240, title = {Selected Lectures of the 14th International Workshop on Neonatology. LECT 31, Unraveling the complex genetics of childhood and adolescent psychopathology, including aggression, through international collaborations: update on the CAPICE and ACTION projects}, journal = {Journal of Pediatric and Neonatal Individualized Medicine (JPNIM)}, volume = {7}, year = {2018}, month = {10/2018}, pages = {38-39}, type = {Proceedings of the 14{\textdegree} International Workshop on Neonatology, The revolution of microbiomics, Cagliari (Italy), October 24-27}, doi = {10.7363/070238}, url = {http://www.jpnim.com/index.php/jpnim/article/view/070238}, author = {Mirko Manchia and Vassilios Fanos} } @article {209, title = {Selected Lectures of the 13th International Workshop on Neonatology. LECT 70, Integrating microbiomics and metabolomics data in behavioral complex traits: a role in aggression?}, journal = {Journal of Pediatric and Neonatal Individualized Medicine (JPNIM)}, volume = {6}, year = {2017}, month = {10/2017}, pages = {96}, type = {Proceedings of the 13{\textdegree} International Workshop on Neonatology, Twins: identical but different, Cagliari (Italy), October 25-28}, abstract = {

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}, keywords = {13th International Workshop on Neonatology, 2017, Aggression, Cagliari}, doi = {10.7363/060235}, url = {http://www.jpnim.com/index.php/jpnim/article/view/060235/467}, author = {Mirko Manchia and Vassilios Fanos} } @article {170, title = {Targeting aggression in severe mental illness: the predictive role of genetic, epigenetic, and metabolomic markers}, journal = {Progress in Neuro-Psychopharmacology and Biological Psychiatry}, volume = {77,}, year = {2017}, month = {07/2017}, pages = {32{\textendash}41}, abstract = {

Human aggression is a complex and widespread social behavior that is overrepresented in individuals affected by severe mental illness (SMI), such as schizophrenia (SCZ), bipolar disorder (BD), autism spectrum disorder (ASD), and attention-deficit/hyperactivity disorder (ADHD). A substantial proportion of the liability threshold for aggressive behavior is determined by genetic factors, and environmental moderators might precipitate the manifestation of this behavioral phenotype through modification of gene expression via the epigenetic machinery. These specific alterations in the genetic and epigenetic make-up of aggressive individuals might determine distinct biochemical signatures detectable through metabolomics. An additional pathophysiological component playing a role in aggressive behavior might be determined by alterations of gut microbiota. Here, we present a selective review of human data on genetic, epigenetic, and metabolomic markers of aggressive behavior in SMI, discussing also the available evidence on the role of microbiome alterations. Clinical implication of these evidences, as well as future perspectives, will be discussed.

}, doi = {http://doi.org/10.1016/j.pnpbp.2017.03.024}, author = {Mirko Manchia and Vassilios Fanos} } @article {162, title = {Fetal programming of neuropsychiatric disorders.}, journal = {Birth Defects Res C Embryo Today}, volume = {108}, year = {2016}, month = {2016 Sep}, pages = {207-223}, abstract = {

Starting from the Developmental Origins of Health and Disease (DOHaD) hypotheses proposed by David Barker, namely fetal programming, in the past years, there is a growing evidence of the major role played by epigenetic factors during the intrauterine life and the perinatal period. Furthermore, it has been assessed that these factors can affect the health status in infancy and even in adulthood. In this review, we focus our attention on the fetal programming of the brain, analyzing the most recent literature concerning the epigenetic factors that can influence the development of neuropsychiatric disorders such as bipolar disorders, major depressive disorders, and schizophrenia. The perinatal epigenetic factors have been divided in two main groups: maternal factors and fetal factors. The maternal factors include diet, smoking, alcoholism, hypertension, malnutrition, trace elements, stress, diabetes, substance abuse, and exposure to environmental toxicants, while the fetal factors include hypoxia/asphyxia, placental insufficiency, prematurity, low birth weight, drugs administered to the mother or to the baby, and all factors causing intrauterine growth restriction. A better comprehension of the possible mechanisms underlying the pathogenesis of these diseases may help researchers and clinicians develop new diagnostic tools and treatments to offer these patients a tailored medical treatment strategy to improve their quality of life. Birth Defects Research (Part C) 108:207-223, 2016. \© 2016 Wiley Periodicals, Inc.

}, issn = {1542-9768}, doi = {10.1002/bdrc.21139}, author = {Faa, Gavino and Mirko Manchia and Pintus, Roberta and Gerosa, Clara and Marcialis, Maria Antonietta and Vassilios Fanos} } @article {159, title = {Selected Lectures of the 12th International Workshop on Neonatology. LECT 59, Metabolomics and aggression (ACTION Project)}, journal = {Journal of Pediatric and Neonatal Individualized Medicine (JPNIM)}, volume = {5}, year = {2016}, month = {10/2015}, pages = {68-70}, type = {Proceedings of the 12{\textdegree} International Workshop on Neonatology and Satellite Meetings, Cagliari (Italy), October 19-22}, abstract = {

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}, keywords = {12th International Workshop on Neonatology, 2016, Cagliari}, doi = {10.7363/050246}, url = {http://www.jpnim.com/index.php/jpnim/article/view/050246}, author = {Mirko Manchia and Antonio Noto} } @article {78, title = {Selected Abstracts of the 11th International Workshop on Neonatology. ABS 100, Brain misteries from the womb to the adult: is aggression congenital?}, journal = {Journal of Pediatric and Neonatal Individualized Medicine (JPNIM)}, volume = {4}, year = {2015}, month = {10/2015}, pages = {231}, type = {Proceedings of the 11{\textdegree} International Workshop on Neonatology and Satellite Meetings, Cagliari (Italy), October 26-31}, abstract = {

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}, doi = {10.7363/040249}, url = {http://www.jpnim.com/index.php/jpnim/article/view/040249}, author = {Mirko Manchia and Vassilios Fanos} }