@article {465, title = {Overview of CAPICE - Childhood and Adolescence Psychopathology: unravelling the complex etiology by a large Interdisciplinary Collaboration in Europe - an EU Marie Sk{\l}odowska-Curie International Training Network}, journal = {European Child \& Adolescent Psychiatry}, volume = {31}, year = {2022}, pages = {829{\textendash}839}, abstract = {

The Roadmap for Mental Health and Wellbeing Research in Europe (ROAMER) identified child and adolescent mental illness as a priority area for research. CAPICE (Childhood and Adolescence Psychopathology: unravelling the complex etiology by a large Interdisciplinary Collaboration in Europe) is a European Union (EU) funded training network aimed at investigating the causes of individual differences in common childhood and adolescent psychopathology, especially depression, anxiety, and attention deficit hyperactivity disorder. CAPICE brings together eight birth and childhood cohorts as well as other cohorts from the EArly Genetics and Life course Epidemiology (EAGLE) consortium, including twin cohorts, with unique longitudinal data on environmental exposures and mental health problems, and genetic data on participants. Here we describe the objectives, summarize the methodological approaches and initial results, and present the dissemination strategy of the CAPICE network. Besides identifying genetic and epigenetic variants associated with these phenotypes, analyses have been performed to shed light on the role of genetic factors and the interplay with the environment in influencing the persistence of symptoms across the lifespan. Data harmonization and building an advanced data catalogue are also part of the work plan. Findings will be disseminated to non-academic parties, in close collaboration with the Global Alliance of Mental Illness Advocacy Networks-Europe (GAMIAN-Europe).

}, keywords = {anxiety, Attention deficit hyperactivity disorder (ADHD), Childhood and adolescence psychopathology, Depression, Psychiatric genetics}, doi = {10.1007/s00787-020-01713-2}, author = {Rajula, Hema Sekhar Reddy and Manchia, Mirko and Agarwal, Kratika and Akingbuwa, Wonuola A and Allegrini, Andrea G and Diemer, Elizabeth and Doering, Sabrina and Haan, Elis and Jami, Eshim S and Karhunen, Ville and Leone, Marica and Schellhas, Laura and Thompson, Ashley and van den Berg, St{\'e}phanie M and Bergen, Sarah E and Kuja-Halkola, Ralf and Hammerschlag, Anke R and J{\"a}rvelin, Marjo Riitta and Leval, Amy and Lichtenstein, Paul and Lundstr{\"o}m, Sebastian and Mauri, Matteo and Munaf{\`o}, Marcus R and Myers, David and Plomin, Robert and Rimfeld, Kaili and Tiemeier, Henning and Ystrom, Eivind and Fanos, Vassilios and Bartels, Meike and Middeldorp, Christel M} } @article {450, title = {Teacher-rated aggression and co-occurring behaviors and emotional problems among schoolchildren in four population-based European cohorts}, journal = {PLoS One}, volume = {16}, year = {2021}, pages = {e0238667}, abstract = {

Aggressive behavior in school is an ongoing concern. The current focus is on specific manifestations such as bullying, but the behavior is broad and heterogenous. Children spend a substantial amount of time in school, but their behaviors in the school setting tend to be less well characterized than at home. Because aggression may index multiple behavioral problems, we used three validated instruments to assess means, correlations and gender differences of teacher-rated aggressive behavior with co-occurring externalizing/internalizing problems and social behavior in 39,936 schoolchildren aged 7-14 from 4 population-based cohorts from Finland, the Netherlands, and the UK. Correlations of aggressive behavior were high with all other externalizing problems (r: 0.47-0.80) and lower with internalizing problems (r: 0.02-0.39). A negative association was observed with prosocial behavior (r: -0.33 to -0.54). Mean levels of aggressive behavior differed significantly by gender. Despite the higher mean levels of aggressive behavior in boys, the correlations were notably similar for boys and girls (e.g., aggressive-hyperactivity correlations: 0.51-0.75 boys, 0.47-0.70 girls) and did not vary greatly with respect to age, instrument or cohort. Thus, teacher-rated aggressive behavior rarely occurs in isolation; boys and girls with problems of aggressive behavior likely require help with other behavioral and emotional problems. Important to note, higher aggressive behavior is not only associated with higher amounts of other externalizing and internalizing problems but also with lower levels of prosocial behavior.

}, doi = {10.1371/journal.pone.0238667}, author = {Whipp, Alyce M and Vuoksimaa, Eero and Bolhuis, Koen and de Zeeuw, Eveline L and Korhonen, Tellervo and Mauri, Matteo and Pulkkinen, Lea and Rimfeld, Kaili and Rose, Richard J and van Beijsterveldt, Catharina Toos E M and Bartels, Meike and Plomin, Robert and Tiemeier, Henning and Kaprio, Jaakko and Boomsma, Dorret I} } @article {230, title = {Childhood aggression and the co-occurrence of behavioural and emotional problems: results across ages 3{\textendash}16~years from multiple raters in six cohorts in the EU-ACTION project}, journal = {European Child {\&} Adolescent Psychiatry}, year = {2018}, month = {May}, abstract = {

Childhood aggression and its resulting consequences inflict a huge burden on affected children, their relatives, teachers, peers and society as a whole. Aggression during childhood rarely occurs in isolation and is correlated with other symptoms of childhood psychopathology. In this paper, we aim to describe and improve the understanding of the co-occurrence of aggression with other forms of childhood psychopathology. We focus on the co-occurrence of aggression and other childhood behavioural and emotional problems, including other externalising problems, attention problems and anxiety\–depression. The data were brought together within the EU-ACTION (Aggression in Children: unravelling gene-environment interplay to inform Treatment and InterventiON strategies) project. We analysed the co-occurrence of aggression and other childhood behavioural and emotional problems as a function of the child\&$\#$39;s age (ages 3 through 16\ years), gender, the person rating the behaviour (father, mother or self) and assessment instrument. The data came from six large population-based European cohort studies from the Netherlands (2x), the UK, Finland and Sweden (2x). Multiple assessment instruments, including the Child Behaviour Checklist (CBCL), the Strengths and Difficulties Questionnaire (SDQ) and Multidimensional Peer Nomination Inventory (MPNI), were used. There was a good representation of boys and girls in each age category, with data for 30,523 3- to 4-year-olds (49.5{\%} boys), 20,958 5- to 6-year-olds (49.6{\%} boys), 18,291 7- to 8-year-olds (49.0{\%} boys), 27,218 9- to 10-year-olds (49.4{\%} boys), 18,543 12- to 13-year-olds (48.9{\%} boys) and 10,088 15- to 16-year-olds (46.6{\%} boys). We replicated the well-established gender differences in average aggression scores at most ages for parental ratings. The gender differences decreased with age and were not present for self-reports. Aggression co-occurred with the majority of other behavioural and social problems, from both externalising and internalising domains. At each age, the co-occurrence was particularly prevalent for aggression and oppositional and ADHD-related problems, with correlations of around 0.5 in general. Aggression also showed substantial associations with anxiety\–depression and other internalizing symptoms (correlations around 0.4). Co-occurrence for self-reported problems was somewhat higher than for parental reports, but we found neither rater differences, nor differences across assessment instruments in co-occurrence patterns. There were large similarities in co-occurrence patterns across the different European countries. Finally, co-occurrence was generally stable across age and sex, and if any change was observed, it indicated stronger correlations when children grew older. We present an online tool to visualise these associations as a function of rater, gender, instrument and cohort. In addition, we present a description of the full EU-ACTION projects, its first results and the future perspectives.

Related interactive tool here.

}, issn = {1435-165X}, doi = {10.1007/s00787-018-1169-1}, url = {https://doi.org/10.1007/s00787-018-1169-1}, author = {Meike Bartels and Anne Hendriks and Matteo Mauri and Eva Krapohl and Alyce Whipp and Koen Bolhuis and Conde, Lucia Colodro and Luningham, Justin and Fung Ip, Hill and Fiona Hagenbeek and Roetman, Peter and Gatej, Raluca and Lamers, Audri and Michel G. Nivard and Jenny van Dongen and Lu, Yi and Christel Middeldorp and van Beijsterveldt, Toos and Vermeiren, Robert and Thomas Hankemeier and Kluft, Cees and Medland, Sarah and Lundstr{\"o}m, Sebastian and Richard J. Rose and Pulkkinen, Lea and Vuoksimaa, Eero and Korhonen, Tellervo and Martin, Nicholas G. and Gitta Lubke and Catrin Finkenauer and Vassilios Fanos and Henning Tiemeier and Lichtenstein, Paul and Robert Plomin and Kaprio, Jaakko and Dorret I. Boomsma} } @article {238, title = {Selected Abstracts of the 14th International Workshop on Neonatology. ABS 36, ACTION {\textendash} Aggression in Children: unraveling gene-environment interplay to inform Treatment and InterventioN strategies}, journal = {Journal of Pediatric and Neonatal Individualized Medicine (JPNIM)}, volume = {7}, year = {2018}, month = {10/2018}, pages = {32-33}, type = {Proceedings of the 14{\textdegree} International Workshop on Neonatology, The revolution of microbiomics, Cagliari (Italy), October 24-27}, doi = {10.7363/070237}, url = {http://www.jpnim.com/index.php/jpnim/article/view/070237}, author = {Matteo Mauri and ACTION Consortium} } @article {239, title = {Selected Lectures of the 14th International Workshop on Neonatology. LECT 33, Sharing research: communication can help}, journal = {Journal of Pediatric and Neonatal Individualized Medicine (JPNIM)}, volume = {7}, year = {2018}, month = {10/2018}, pages = {41-43}, type = {Proceedings of the 14{\textdegree} International Workshop on Neonatology, The revolution of microbiomics, Cagliari (Italy), October 24-27}, doi = {10.7363/070238}, url = {http://www.jpnim.com/index.php/jpnim/article/view/070238}, author = {Matteo Mauri and Vassilios Fanos} } @article {212, title = {Selected Abstracts of the 13th International Workshop on Neonatology. ABS 72, An interactive tool shows comorbidities of child aggression with other childhood psychopathologies. Utilities and statistics of the website www.action-euproject.eu}, journal = {Journal of Pediatric and Neonatal Individualized Medicine (JPNIM)}, volume = {6}, year = {2017}, month = {10/2017}, type = {Proceedings of the 13{\textdegree} International Workshop on Neonatology, Twins: identical but different, Cagliari (Italy), October 25-28}, doi = {10.7363/060234}, url = {http://www.jpnim.com/index.php/jpnim/article/view/060234/468}, author = {Matteo Mauri and Anne Hendriks and Vassilios Fanos and Dorret I. Boomsma and Meike Bartels} } @article {75, title = {DisseminACTION: disseminating science in the information age (www.action-euproject.eu: a website for researchers and parents)}, journal = {Journal of Pediatric and Neonatal Individualized Medicine (JPNIM)}, volume = {4}, year = {2015}, month = {10/2015}, pages = {103-110}, type = {Proceedings of the 11{\textdegree} International Workshop on Neonatology and Satellite Meetings, Cagliari (Italy), October 26-31}, abstract = {

www.action-euproject.eu is a website designed at the University of Cagliari, by the Department of Surgery, Faculty of Medicine, within the project \“ACTION - Aggression in Children: unravelling gene-environment interplay to inform Treatment and InterventiON strategies\”, a collaborative project which includes twelve international partners, funded under the 7th Framework Programme for Research, technological Development and Demonstration.

Its aim is to properly disseminate official news, events, medical discoveries carried out within the project, with an intent to connect European researchers and citizens with the official source of ACTION\’s scientific research.

One of the main problems of the so called Web 2.0., is represented by the growth of viral misinformation, which contributes to create rumours and hoaxes around scientific threads. In order to avoid this kind of problems, www.action-euproject.eu is also designed to directly reach its audience even with social networks integration and with newsletters.


Informatics is the discipline that studies the information processing through automated elaborations. The term appears for the first time in 1957, and since that time Computer Science has grown, reaching an unthinkable evolution, so that the common devices we use in our everyday lives (personal computers, notebooks, tablets, smartphones) are more powerful than the NASA calculators at the time of moon\’s landing. This evolution leads to privacy and security matters: our devices process everyday an important number of sensitive data, and are everyday exposed to the risks of computer security.

This website has been designed following usability guidelines, with a logical sitemap, an easy system of options, a clear graphic style, a responsive graphic template and a robust Content Management System, in order to ensure the website security and a rigid privacy policy.

Complete Article

}, keywords = {computer security, misinformation, privacy, scientific dissemination, usability, Website}, doi = {10.7363/040254}, url = {http://www.jpnim.com/index.php/jpnim/article/view/040254}, author = {Matteo Mauri} }