@article {270,
	title = {Widespread covariation of early environmental exposures and trait-associated polygenic variation},
	journal = {Proceedings of the National Academy of Sciences},
	volume = {114},
	year = {2017},
	pages = {11727{\textendash}11732},
	abstract = {<p>Environmental exposures are among the best predictors of health and educational outcomes. Models that estimate the effect of environmental exposures on developmental outcomes typically ignore genetic factors or focus on gene\&ndash;environment interaction (whether individuals\&rsquo; response to environmental exposures depends on their genotype). Here we test gene\&ndash;environment correlation (whether individuals\&rsquo; exposure to environments depends on their genotype). Using a method that tests specific genetic effects while controlling for background genetic effects, we estimate covariation between children\&rsquo;s genetic liability/propensity for core developmental outcomes and a wide range of environmental exposures. Findings suggest that genetic variants associated with traits, such as educational attainment, body mass index, and schizophrenia, also capture environmental risk and protective factors.Although gene\&ndash;environment correlation is recognized and investigated by family studies and recently by SNP-heritability studies, the possibility that genetic effects on traits capture environmental risk factors or protective factors has been neglected by polygenic prediction models. We investigated covariation between trait-associated polygenic variation identified by genome-wide association studies (GWASs) and specific environmental exposures, controlling for overall genetic relatedness using a genomic relatedness matrix restricted maximum-likelihood model. In a UK-representative sample (n = 6,710), we find widespread covariation between offspring trait-associated polygenic variation and parental behavior and characteristics relevant to children\&rsquo;s developmental outcomes\&mdash;independently of population stratification. For instance, offspring genetic risk for schizophrenia was associated with paternal age (R2 = 0.002; P = 1e-04), and offspring education-associated variation was associated with variance in breastfeeding (R2 = 0.021; P = 7e-30), maternal smoking during pregnancy (R2 = 0.008; P = 5e-13), parental smacking (R2 = 0.01; P = 4e-15), household income (R2 = 0.032; P = 1e-22), watching television (R2 = 0.034; P = 5e-47), and maternal education (R2 = 0.065; P = 3e-96). Education-associated polygenic variation also captured covariation between environmental exposures and children\&rsquo;s inattention/hyperactivity, conduct problems, and educational achievement. The finding that genetic variation identified by trait GWASs partially captures environmental risk factors or protective factors has direct implications for risk prediction models and the interpretation of GWAS findings.</p>
},
	issn = {0027-8424},
	doi = {10.1073/pnas.1707178114},
	url = {https://www.pnas.org/content/114/44/11727},
	author = {Eva Krapohl and Hannigan, L. J. and Pingault, J.-B. and Patel, H. and Kadeva, N. and Curtis, C. and Breen, G. and Newhouse, S. J. and Thalia C. Eley and Paul F O{\textquoteright}Reilly and Robert Plomin}
}
