DNA methylation signatures of aggression and closely related constructs: A meta-analysis of epigenome-wide studies across the lifespan
| Title | DNA methylation signatures of aggression and closely related constructs: A meta-analysis of epigenome-wide studies across the lifespan |
| Publication Type | Journal Article |
| Year of Publication | 2021 |
| Authors | van Dongen, J, Hagenbeek, FA, Suderman, M, Roetman, PJ, Sugden, K, Chiocchetti, AG, Ismail, K, Mulder, RH, Hafferty, JD, Adams, MJ, Walker, RM, Morris, SW, Lahti, J, Küpers, LK, Escaramis, G, Alemany, S, Bonder, MJan, Meijer, M, Ip, HF, Jansen, R, Baselmans, BML, Parmar, P, Lowry, E, Streit, F, Sirignano, L, Send, TS, Frank, J, Jylhävä, J, Wang, Y, Mishra, PPrasad, Colins, OF, Corcoran, DL, Poulton, R, Mill, J, Hannon, E, Arseneault, L, Korhonen, T, Vuoksimaa, E, Felix, JF, Bakermans-Kranenburg, MJ, Campbell, A, Czamara, D, Binder, E, Corpeleijn, E, Gonzalez, JR, Grazuleviciene, R, Gutzkow, KB, Evandt, J, Vafeiadi, M, Klein, M, van der Meer, D, Ligthart, L, Consortium, BIOS, Kluft, C, Davies, GE, Hakulinen, C, Keltikangas-Järvinen, L, Franke, B, Freitag, CM, Konrad, K, Hervas, A, Fernández-Rivas, A, Vetro, A, Raitakari, O, Lehtimäki, T, Vermeiren, R, Strandberg, T, Räikkönen, K, Snieder, H, Witt, SH, Deuschle, M, Pedersen, NL, Hägg, S, Sunyer, J, Franke, L, Kaprio, J, Ollikainen, M, Moffitt, TE, Tiemeier, H, van IJzendoorn, MH, Relton, C, Vrijheid, M, Sebert, S, Jarvelin, M-R, Caspi, A, Evans, KL, McIntosh, AM, Bartels, M, Boomsma, DI |
| Journal | Molecular Psychiatry |
| Volume | 26 |
| Pagination | 2148–2162 |
| Abstract | DNA methylation profiles of aggressive behavior may capture lifetime cumulative effects of genetic, stochastic, and environmental influences associated with aggression. Here, we report the first large meta-analysis of epigenome-wide association studies (EWAS) of aggressive behavior (N = 15,324 participants). In peripheral blood samples of 14,434 participants from 18 cohorts with mean ages ranging from 7 to 68 years, 13 methylation sites were significantly associated with aggression (alpha = 1.2 $\times$ 10-7; Bonferroni correction). In cord blood samples of 2425 children from five cohorts with aggression assessed at mean ages ranging from 4 to 7 years, 83% of these sites showed the same direction of association with childhood aggression (r = 0.7 |
| DOI | 10.1038/s41380-020-00987-x |
