Genome-wide association meta-analysis of childhood and adolescent internalizing symptoms
| Title | Genome-wide association meta-analysis of childhood and adolescent internalizing symptoms |
| Publication Type | Journal Article |
| Year of Publication | 2022 |
| Authors | Jami, ES, Hammerschlag, AR, Ip, HF, Allegrini, AG, Benyamin, B, Border, R, Diemer, EW, Jiang, C, Karhunen, V, Lu, Y, Lu, Q, Mallard, TT, Mishra, PP, Nolte, IM, Palviainen, T, Peterson, RE, Sallis, HM, Shabalin, AA, Tate, AE, Thiering, E, Vilor-Tejedor, N, Wang, C, Zhou, A, Adkins, DE, Alemany, S, Ask, H, Chen, Q, Corley, RP, Ehli, EA, Evans, LM, Havdahl, A, Hagenbeek, FA, Hakulinen, C, Henders, AK, Hottenga, JJan, Korhonen, T, Mamun, A, Marrington, S, Neumann, A, Rimfeld, K, Rivadeneira, F, Silberg, JL, van Beijsterveldt, CE, Vuoksimaa, E, Whipp, AM, Tong, X, Andreassen, OA, Boomsma, DI, Brown, SA, S Burt, A, Copeland, W, Dick, DM, K Harden, P, Harris, KMullan, Hartman, CA, Heinrich, J, Hewitt, JK, Hopfer, C, Hypponen, E, Jarvelin, M-R, Kaprio, J, Keltikangas-Järvinen, L, Klump, KL, Krauter, K, Kuja-Halkola, R, Larsson, H, Lehtimäki, T, Lichtenstein, P, Lundström, S, Maes, HH, Magnus, P, Munafò, MR, Najman, JM, Njølstad, P\aalR, Oldehinkel, AJ, Pennell, CE, Plomin, R, Reichborn-Kjennerud, T, Reynolds, C, Rose, RJ, Smolen, A, Snieder, H, Stallings, M, Standl, M, Sunyer, J, Tiemeier, H, Wadsworth, SJ, Wall, TL, Whitehouse, AJO, Williams, GM, Ystrøm, E, Nivard, MG, Bartels, M, Middeldorp, CM |
| Journal | Journal of the American Academy of Child & Adolescent Psychiatry |
| Volume | 61 |
| Pagination | 934–945 |
| Keywords | anxiety, Depression, genetic epidemiology, molecular genetics, repeated measures |
| Abstract | OBJECTIVE: To investigate the genetic architecture of internalizing symptoms in childhood and adolescence. METHOD: In 22 cohorts, multiple univariate genome-wide association studies (GWASs) were performed using repeated assessments of internalizing symptoms, in a total of 64,561 children and adolescents between 3 and 18 years of age. Results were aggregated in meta-analyses that accounted for sample overlap, first using all available data, and then using subsets of measurements grouped by rater, age, and instrument. RESULTS: The meta-analysis of overall internalizing symptoms (INToverall) detected no genome-wide significant hits and showed low single nucleotide polymorphism (SNP) heritability (1.66%, 95% CI = 0.84-2.48 |
| DOI | 10.1016/j.jaac.2021.11.035 |
